Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994

Garchon H J, Djabiri F, Viard J P, Gajdos P, Bach J F

Abstract excerpt

The muscle acetylcholine receptor is the major target of the autoimmune response in generalized myasthenia gravis. To investigate the role of the gene encoding the alpha subunit of the receptor (CHRNA), two stable polymorphic d[(GT).(CA)]dinucleotide repeats, designated HB and BB, were characterized within the first intron of CHRNA. The HB*14 allele conferred a relative risk for myasthenia gravis of 2.5 in 81...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Molecular Sequence Data

Share to Pedigree

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 7910962
DOI: 10.1073/pnas.91.11.4668
PMCID: PMC43849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis.PMID 7910962Read ↗

Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.Semantic proximity Read ↗

No evidence for an association of AChR beta-subunit gene (CHRNB1) with myasthenia gravis.Semantic proximity Read ↗

Association of the gene encoding the delta-subunit of the muscle acetylcholine receptor (CHRND) with acquired autoimmune myasthenia gravis.Semantic proximity Read ↗

Gene Polymorphisms for Both Auto-antigen and Immune-Modulating Proteins Are Associated with the Susceptibility of Autoimmune Myasthenia Gravis.Semantic proximity Read ↗

Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study.Semantic proximity Read ↗

Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man.Semantic proximity Read ↗

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.Semantic proximity Read ↗

Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasiaSemantic proximity Read ↗

Acetylcholine receptors and myasthenia.Semantic proximity Read ↗

Immunoglobulin heavy chain gene associations in myasthenia gravis: new evidence for disease heterogeneity.Semantic proximity Read ↗

Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase.Semantic proximity Read ↗

SSCP variants within the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.