Article
Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994
Garchon H J, Djabiri F, Viard J P, Gajdos P, Bach J F
Abstract excerpt
The muscle acetylcholine receptor is the major target of the autoimmune response in generalized myasthenia gravis. To investigate the role of the gene encoding the alpha subunit of the receptor (CHRNA), two stable polymorphic d[(GT).(CA)]dinucleotide repeats, designated HB and BB, were characteri...
Topics
- Adolescent
- Adult
- Alleles
- Base Sequence
- Child
- DNA, Satellite
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Muscles
- Myasthenia Gravis
- Pedigree
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length