Article
Human major histocompatibility complex contains several leukemia susceptibility genes.
Leukemia & lymphoma - 1 Jan 1994
Dorak M T, Chalmers E A, Gaffney D, Wilson D W, Galbraith I, Henderson N, Worwood M, Mills K I, Burnett A K
Abstract excerpt
In mice, homozygosity for the Mhc haplotype H-2k is associated with increased susceptibility to spontaneous and virus-induced leukemia, lymphoma and other neoplasms in the predisposed host. The influence of the Mhc on malignant development in these models is to shorten the latency after virus inoculation. Here, we present evidence that a similar phenomenon results in early-onset of human leukemia. A molecular...
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