Article
Human major histocompatibility complex contains several leukemia susceptibility genes.
Leukemia & lymphoma - 1 Jan 1994
Dorak M T, Chalmers E A, Gaffney D, Wilson D W, Galbraith I, Henderson N, Worwood M, Mills K I, Burnett A K
Abstract excerpt
In mice, homozygosity for the Mhc haplotype H-2k is associated with increased susceptibility to spontaneous and virus-induced leukemia, lymphoma and other neoplasms in the predisposed host. The influence of the Mhc on malignant development in these models is to shorten the latency after virus ino...
Topics
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Cell Line
- Child
- Child, Preschool
- Disease Susceptibility
- Genetic Predisposition to Disease
- H-2 Antigens
- HLA-A Antigens
- HLA-B Antigens
- HLA-D Antigens
- Humans
- Leukemia
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive