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Article

Adhesin regulatory genes within large, unstable DNA regions of pathogenic Escherichia coli: cross-talk between different adhesin gene clusters.

Molecular microbiology - 1 Feb 1994

Morschhäuser J, Vetter V, Emödy L, Hacker J

Abstract excerpt

The uropathogenic Escherichia coli strain 536 possesses two large, unstable DNA regions on its chromosome, which were termed pathogenicity islands (pais). Deletions of pais, which occur with relatively high frequency in vitro and in vivo, lead to avirulent mutants. The genetic determinants for production of haemolysin (Hly) and P-related fimbriae (Prf) are located in one of these islands. Deletion of this...

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PMID: 7908714
DOI: 10.1111/j.1365-2958.1994.tb00336.x

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