Article
Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 1993
Bahary N, Siegel D A, Walsh J, Zhang Y, Leopold L, Leibel R, Proenca R, Friedman J M
Abstract excerpt
In a previous report, the ob mutation was mapped to a position 5 cM distal to Met on murine Chromosome (Chr) 6 in tight linkage to Cpa. In order to identify additional RFLPs in the region of ob, we have made use of chromosome microdissection of a 6:16 Robertsonian chromosome. In total, 19 RFLPs were used to type 131 progency of a B6D2 ob/ + x B6 spretus ob/ + intercross. Fifteen of the RFLPs mapped to Chr 6, one...
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