Article
Standard conditions of virus isolation reveal biological variability of HIV type 1 in different regions of the world. WHO Network for HIV Isolation and Characterization.
AIDS research and human retroviruses - 1 Nov 1994
Rübsamen-Waigmann H, von Briesen H, Holmes H, Björndal A, Korber B, Esser R, Ranjbar S, Tomlinson P, Galvao-Castro B, Karita E
Abstract excerpt
HIV-1 isolates were obtained from four countries within the framework of the WHO Network for HIV Isolation and Characterization. The use of standard HIV isolation procedures allowed us to compare the biological properties of 126 HIV-1 isolates spanning five genetic subtypes. In primary isolation cultures, viruses from Uganda and Brazil appeared early and replicated without delay, whereas the replication of Thai...
Topics
- Brazil
- Cell Line
- Cells, Cultured
- Cytopathogenic Effect, Viral
- Genetic Variation
- Genotype
- HIV Infections
- HIV-1
- Humans
- Leukocytes, Mononuclear