Cytogenetic response to asbestos fibers in cultured human primary mesothelial cells from 10 different donors.

doi:10.1016/0165-1161(95)90015-2

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Article

Cytogenetic response to asbestos fibers in cultured human primary mesothelial cells from 10 different donors.

Mutation research - 1 Apr 1995

Pelin K, Hirvonen A, Taavitsainen M, Linnainmaa K

Abstract excerpt

The ability of amosite asbestos fibers to induce chromosomal aberrations in human primary mesothelial cells obtained from pleural effusions of 10 noncancerous patients was investigated. The glutathione S-transferase M1 (GSTM1) genotypes of the patients were determined, since the GSTM1 null genotype has been associated with increased susceptibility to lung cancer and chemically induced cytogenetic damage. Four of...

Topics

Adult
Aged
Aged, 80 and over
Asbestos, Amosite
Cell Division
Cells, Cultured
Chromosome Aberrations
Epithelium
Female
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutathione Transferase

Humans

Male

Middle Aged

Mitotic Index

Pleural Effusion

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7885376
DOI: 10.1016/0165-1161(95)90015-2

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7885376-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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