Mechanisms of asbestos-induced carcinogenesis.

doi:10.18999/nagjms.71.1-2.1

Article

Mechanisms of asbestos-induced carcinogenesis.

1 Feb 2009

Abstract excerpt

Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding the pathogenesis of asbestos-induced DMM, which may be summarized as follows: (1) the "oxidative...

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