mRNA phenotyping of the major ligands and receptors of the EGF supergene family in human ovarian epithelial cells.

doi:10.1016/0304-3835(95)90159-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

mRNA phenotyping of the major ligands and receptors of the EGF supergene family in human ovarian epithelial cells.

Cancer letters - 10 Feb 1995

Gordon A W, Pegues J C, Johnson G R, Kannan B, Auersperg N, Stromberg K

Abstract excerpt

mRNA amplification phenotyping (MAPPing) was used to determine the level of mRNA expression of the major EGF-related ligands (EGF, TGF-alpha, and Amphiregulin) and receptors (EGF-receptor and erbB-2) of the EGF supergene family in three ovarian carcinoma lines (OVCA 429 and 433, and NIH:OVCAR-8) under serum-supplemented and reduced serum (minimal medium with 2% fetuin) growth conditions. mRNA levels of TGF-alpha,...

Topics

Amphiregulin
Base Sequence
DNA, Neoplasm
EGF Family of Proteins
Epidermal Growth Factor
Epithelium
ErbB Receptors
Female
Gene Amplification
Glycoproteins
Growth Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Intercellular Signaling Peptides and Proteins

Ligands

Molecular Sequence Data

Ovarian Neoplasms

Phenotype

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 7882303
DOI: 10.1016/0304-3835(95)90159-0

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7882303-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

mRNA phenotyping of the major ligands and receptors of the EGF supergene family in human ovarian epithelial cells.PMID 7882303Read ↗

Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma.Semantic proximity Read ↗

Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissuesSemantic proximity Read ↗

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory ActivitySemantic proximity Read ↗

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.Semantic proximity Read ↗

Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family.Semantic proximity Read ↗

A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin.Semantic proximity Read ↗

Gene structure and expression analysis of the epidermal growth factor receptor, transforming growth factor-alpha, myc, jun, and metallothionein in human ovarian carcinomas. Classification of malignant phenotypes.Semantic proximity Read ↗

Amplification of oncogenes revisited: from expression profiling to clinical applicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.