Article
Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation.
Virology - 20 Feb 1995
Mahalingam S, Khan S A, Jabbar M A, Monken C E, Collman R G, Srinivasan A
Abstract excerpt
Vpr is one of the auxiliary proteins encoded by the HIV-1 genome and is selectively incorporated into the virus particle. It has been shown that Vpr incorporation in the virus particle requires only the core protein Gag. In an effort to identify the domains of Vpr which are essential for incorporation into the HIV-1 virion, site-specific mutagenesis of vpr was carried out. Mutation of the highly conserved acidic...
Topics
- Amino Acids
- Base Sequence
- Conserved Sequence
- Gene Expression
- Gene Products, gag
- Gene Products, vpr
- Genes, vpr
- Genetic Vectors
- HIV-1
- HeLa Cells
- Humans