Functional role of residues corresponding to helical domain II (amino acids 35 to 46) of human immunodeficiency virus type 1 Vpr.

doi:10.1128/jvi.74.22.10650-10657.2000

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Article

Functional role of residues corresponding to helical domain II (amino acids 35 to 46) of human immunodeficiency virus type 1 Vpr.

Journal of virology - 1 Nov 2000

Singh S P, Tomkowicz B, Lai D, Cartas M, Mahalingam S, Kalyanaraman V S, Murali R, Srinivasan A

Abstract excerpt

Vpr, encoded by the human immunodeficiency virus type 1 genome, contains 96 amino acids and is a multifunctional protein with features which include cell cycle arrest at G(2), nuclear localization, participation in transport of the preintegration complex, cation channel activity, oligomerization, and interaction with cellular proteins, in addition to its incorporation into the virus particles. Recently,...

Topics

Amino Acid Sequence
Cell Cycle
Gene Products, vpr
HIV-1
HeLa Cells
Humans
Mutation
Protein Structure, Tertiary
Structure-Activity Relationship
Subcellular Fractions
Transfection
Virion
vpr Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 11044109
DOI: 10.1128/jvi.74.22.10650-10657.2000
PMCID: PMC110939

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