Article
Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene.
Endocrinology - 1 Mar 1995
Rabelo R, Schifman A, Rubio A, Sheng X, Silva J E
Abstract excerpt
Uncoupling protein (UCP) is essential to brown adipose tissue (BAT) thermogenesis and, hence, to cold adaptation and energy balance. The sympathetic nervous system, via norepinephrine and cAMP, and thyroid hormone seem to be the major regulators of UCP expression. T3 potentiates the effect of nor...
Topics
- Animals
- Base Sequence
- Carrier Proteins
- Cell Line
- Enhancer Elements, Genetic
- Genes
- Humans
- Ion Channels
- Lipoma
- Membrane Proteins
- Mitochondria
- Mitochondrial Proteins
- Molecular Sequence Data
- Mutation
- Placenta
- Rats
- Receptors, Thyroid Hormone
- Thyroid Hormones