Article
Phenotypic analysis of yellow fever virus derived from complementary DNA.
The American journal of tropical medicine and hygiene - 1 Jan 1995
Marchevsky R S, Mariano J, Ferreira V S, Almeida E, Cerqueira M J, Carvalho R, Pissurno J W, da Rosa A P, Simoes M C, Santos C N
Abstract excerpt
A thorough phenotypic characterization of yellow fever (YF) virus generated from cDNA is a necessary prerequisite for mapping virulence/attenuation determinants and exploring the potential of YF attenuated virus 17D as a carrier for heterologous protective epitopes. In this study, YF virus was pr...
Topics
- Animals
- Antibodies, Viral
- Cells, Cultured
- Central Nervous System
- Chick Embryo
- DNA, Viral
- Fibroblasts
- Macaca fascicularis
- Macaca mulatta
- Male
- Neutralization Tests
- Phenotype
- Serial Passage
- Transfection
- Vaccines, Attenuated