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Article

A yellow fever 17D and Usutu virus chimera with rationally designed mutations in the envelope protein is lethal in an Ifnar-/- mouse model.

Virology journal - 3 Jul 2026

Duyvestyn Johanna M, Bredenbeek Peter J, Thaler Melissa, Kikkert Marjolein, van Hemert Martijn J

Abstract excerpt

The expanding geographical spread of Usutu virus (USUV) poses an increasing threat to bird populations and to human health. Here we assessed a chimeric USUV vaccine candidate that was constructed using the live attenuated yellow fever virus (YFV) YF-17D platform. In our chimeric virus, the pre-membrane (PrM) and envelope (E) proteins of YFV were replaced with those of USUV. Similar chimeras of YF-17D with...

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Flavivirus
Receptor, Interferon alpha-beta
Survival Analysis
Vaccines, Attenuated
Viral Envelope Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Yellow fever virus

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Identifiers

PMID: 42393766
DOI: 10.1186/s12985-026-03145-x
PMCID: PMC13330216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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