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Article

Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes

1 Jan 2007

Abstract excerpt

BACKGROUND: The yellow fever virus, a member of the genus Flavivirus, is an arthropod-borne pathogen causing severe disease in humans. The attenuated yellow fever 17D virus strain has been used for human vaccination for 70 years and has several characteristics that are desirable for the development of new, live attenuated vaccines. We described here a methodology to construct a viable, and immunogenic recombinant...

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PMID: 17971212
DOI: 10.1186/1743-422x-4-115

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