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Article

Two mutations in NS2B are responsible for attenuation of the yellow fever virus (YFV) vaccine strain 17D.

PLoS pathogens - 1 Jul 2025

Qiu Xueer, Bailey Adam L

Abstract excerpt

Vaccines have done more to improve the health of humankind over the past century than almost any other technology. Among vaccines, the live-attenuated yellow fever (YF) vaccine (17D) is highly effective, providing long-lasting immunity against yellow fever virus (YFV) infection with a single dose. Developed in the 1930s through extensive serial passage of the virulent YFV-Asibi strain through mouse and chicken...

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Identifiers

PMID: 40743291
DOI: 10.1371/journal.ppat.1013373
PMCID: PMC12312905

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