Article
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.
Virology - 25 Nov 2001
Galler R, Pugachev K V, Santos C L, Ocran S W, Jabor A V, Rodrigues S G, Marchevsky R S, Freire M S, Almeida L F, Cruz A C, Yamamura A M, Rocco I M, da Rosa E S, Souza L T, Vasconcelos P F, Guirakhoo F, Monath T P
Abstract excerpt
The yellow fever (YF) 17D virus is one of the most successful vaccines developed to data. Its use has been estimated to be over 400 million doses with an excellent record of safety. In the past 3 years, yellow fever vaccination was intensified in Brazil in response to higher risk of urban outbreaks of the disease. Two fatal adverse events temporally associated with YF vaccination were reported. Both cases had...
Topics
- Animals
- Antibodies, Viral
- Brazil
- Chlorocebus aethiops
- Consumer Product Safety
- Disease Models, Animal
- Female
- Humans
- Macaca mulatta
- Male
- Phenotype
- Sequence Analysis, DNA
- Vaccination