Article
Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARalpha and transcription at the Hmgcs2 PPRE.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2010
Kostiuk Morris A, Keller Bernd O, Berthiaume Luc G
Abstract excerpt
Excessive liver production of ketone bodies is one of many metabolic complications that can arise from diabetes, and in severe untreated cases, it can result in ketoacidosis, coma, and death. Mitochondrial HMG-CoA synthase (HMGCS2), the rate-limiting enzyme in ketogenesis, has been shown to inter...
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