Article
An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2008
Autio Kaija J, Kastaniotis Alexander J, Pospiech Helmut, Miinalainen Ilkka J, Schonauer Melissa S, Dieckmann Carol L, Hiltunen J Kalervo
Abstract excerpt
In bacteria, functionally related gene products are often encoded by a common transcript. Such polycistronic transcripts are rare in eukaryotes. Here we isolated several clones from human cDNA libraries, which rescued the respiratory-deficient phenotype of a yeast mitochondrial 3-hydroxyacyl thioester dehydratase 2 (htd2) mutant strain. All complementing cDNAs were derived from the RPP14 transcript previously...
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