Article
[Detection of methicillin-resistant Staphylococcus aureus using PCR and non-radioactive DNA probes: IV. Mutational sequences in the region upstream of the mec A gene in clinical staphylococcal strains].
Rinsho byori. The Japanese journal of clinical pathology - 1 Nov 1994
Yamashita K, Takarada Y, Muto T, Otsuka N, Kagawa S, Matsuoka A
Abstract excerpt
Expression of mec A is regulated by two regulatory genes (mecR1 and mecI); the intact regulatory genes exist in the N315 strain of methicillin-sensitive S. aureus, whereas the repressor gene (mecI) is deleted in the MR108 strain of methicillin-resistant S. aureus (MRSA). However, our previous findings that clinical strains of N315 type were methicillin-resistant suggest possible mutations within the operator...
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