Article
[Detection of methicillin-resistant Staphylococcus aureus using PCR and non-radioactive DNA probes: III. Mutations of the fem A gene in clinical strains of Staphylococcus aureus].
Rinsho byori. The Japanese journal of clinical pathology - 1 Oct 1994
Yamashita K, Takarada Y, Li L, Otsuka N, Kagawa S, Matsuoka A
Abstract excerpt
Methicillin resistance in S. aureus is primarily due to the presence of the mec A gene. However, in addition to mec, the phenotypic expression of methicillin resistance requires the presence of an additional gene(s), fem A which is chromosomally encoded. Previous studies suggest an increase in the biochemical function of fem A gene products due to base substitutions in the region upstream of the fem A gene and in...
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