Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

doi:10.1242/jcs.107.9.2609

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Article

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

Journal of cell science - 1 Sept 1994

Mayer-Jaekel R E, Ohkura H, Ferrigno P, Andjelkovic N, Shiomi K, Uemura T, Glover D M, Hemmings B A

Abstract excerpt

The 55 kDa regulatory subunit of Drosophila protein phosphatase 2A is located in the cytoplasm at all cell cycle stages, by the criterion of immunofluorescence. We are unable to detect significant change in protein phosphatase activity during the nuclear division cycle of syncytial embryos. However, cell cycle function of the enzyme is suggested by the mitotic defects exhibited by two Drosophila mutants, aar1 and...

Topics

Alleles
Animals
Base Sequence
Brain
CDC2 Protein Kinase
Cell Cycle
Drosophila melanogaster
Embryo, Nonmammalian
Larva
Molecular Sequence Data
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phosphoprotein Phosphatases

Phosphorylation

Protein Conformation

Protein Phosphatase 2

Protein Processing, Post-Translational

Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 7844174
DOI: 10.1242/jcs.107.9.2609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7844174-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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