Article
Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus.
Genomics - 15 Sept 1994
Keller S A, Jones J M, Boyle A, Barrow L L, Killen P D, Green D G, Kapousta N V, Hitchcock P F, Swank R T, Meisler M H
Abstract excerpt
The semidominant mutation Krd (kidney and retinal defects) was identified in transgenic line Tg8052. Krd/+ mice have a high incidence of kidney defects including aplastic, hypoplastic, and cystic kidneys. Retinal defects in Krd/+ mice include abnormal electroretinograms and a reduction of cell numbers that is most extreme in the inner cell and ganglion layers. Viability of Krd/+ mice is strongly influenced by...
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