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Article

A simple method for assessing the mutational effect on the protein-DNA interaction: application to amino acid substitutions.

Protein engineering - 1 Sept 1994

Wang Y, Sarai A

Abstract excerpt

We have developed a simple method to assess the effect of mutations on the binding affinity change in the protein-DNA interaction. In this method, we evaluate the contribution of the local geometric effect in protein-DNA recognition by calculating the change in interaction energy caused by mutations, and assess the binding activity by introducing the binding affinity index. We applied this method to the...

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PMID: 7831278
DOI: 10.1093/protein/7.9.1083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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