Article
A high-throughput percentage-of-binding strategy to measure binding energies in DNA-protein interactions: application to genome-scale site discovery.
Nucleic acids research - 1 Sept 2008
Wang Xiaohu, Gao Haichun, Shen Yufeng, Weinstock George M, Zhou Jizhong, Palzkill Timothy
Abstract excerpt
Quantifying the binding energy in DNA-protein interactions is of critical importance to understand transcriptional regulation. Based on a simple computational model, this study describes a high-throughput percentage-of-binding strategy to measure the binding energy in DNA-protein interactions between the Shewanella oneidensis ArcA two-component transcription factor protein and a systematic set of mutants in an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.