Article
The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin-converting enzyme gene deletion allele.
QJM : monthly journal of the Association of Physicians - 1 Nov 1994
Prasad N, O'Kane K P, Johnstone H A, Wheeldon N M, McMahon A D, Webb D J, MacDonald T M
Abstract excerpt
An insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene accounts for approximately 50% of the variance in plasma ACE concentration: deletion homozygotes (DD) have the highest, and insertion homozygotes (II) the lowest ACE concentrations. ACE is responsible for the gener...
Topics
- Alleles
- Female
- Genotype
- Humans
- Hypertension
- Hypertrophy, Left Ventricular
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
- Sequence Deletion
- Systole