Article
The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin-converting enzyme gene deletion allele.
QJM : monthly journal of the Association of Physicians - 1 Nov 1994
Prasad N, O'Kane K P, Johnstone H A, Wheeldon N M, McMahon A D, Webb D J, MacDonald T M
Abstract excerpt
An insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene accounts for approximately 50% of the variance in plasma ACE concentration: deletion homozygotes (DD) have the highest, and insertion homozygotes (II) the lowest ACE concentrations. ACE is responsible for the generation of angiotensin II, which is implicated in the development of left ventricular hypertrophy, an independent risk...
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