Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the mouse ZP3 combining site for sperm by exon swapping and site-directed mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 1995

Kinloch R A, Sakai Y, Wassarman P M

Abstract excerpt

During fertilization in mice, sperm bind to mouse ZP3 (mZP3), a M(r) approximately 83,000 glycoprotein present in the ovulated egg extracellular coat, or zona pellucida. Sperm recognize and bind to specific serine/threonine-linked (O-linked) oligosaccharides present at the mZP3 combining site for sperm. Binding to mZP3 induces sperm to undergo a form of exocytosis, the acrosome reaction. To map the mZP3 combining...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Binding Sites

Share to Cell Line

Share to DNA Primers

Share to Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 7816829
DOI: 10.1073/pnas.92.1.263
PMCID: PMC42858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the mouse ZP3 combining site for sperm by exon swapping and site-directed mutagenesis.PMID 7816829Read ↗

Inactivation of the mouse sperm receptor, mZP3, by site-directed mutagenesis of individual serine residues located at the combining site for spermSemantic proximity Read ↗

Towards the Molecular Basis of Sperm and Egg Interaction during Mammalian FertilizationSemantic proximity Read ↗

Zona pellucida glycoprotein ZP3 and fertilization in mammalsSemantic proximity Read ↗

Profile of a mammalian sperm receptor1,2Semantic proximity Read ↗

The molecular basis of mouse sperm–zona pellucida binding: a still unresolved issue in developmental biologySemantic proximity Read ↗

Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycansSemantic proximity Read ↗

The molecular basis of gamete recognition in mice and humansSemantic proximity Read ↗

Transgenic mice with reduced numbers of functional sperm receptors on their eggs reproduce normally.Semantic proximity Read ↗

Insights into the molecular basis of sperm–egg recognition in mammalsSemantic proximity Read ↗

Interaction of a Tyrosine Kinase from Human Sperm with the Zona Pellucida at FertilizationSemantic proximity Read ↗

Oligosaccharide Constructs with Defined Structures That Inhibit Binding of Mouse Sperm to Unfertilized Eggs in VitroSemantic proximity Read ↗

Carbohydrates and fertilization: an overviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.