Article
Transgenic mice with reduced numbers of functional sperm receptors on their eggs reproduce normally.
Molecular biology of the cell - 1 May 1995
Liu C, Litscher E S, Wassarman P M
Abstract excerpt
To initiate fertilization in mice, free-swimming sperm bind to mZP3, an approximately 83-kDa glycoprotein present in the ovulated egg zona pellucida (ZP). mZP3 is located periodically along the filaments that constitute the ZP. Sperm recognize and bind to specific oligosaccharides linked to one or more of five Ser residues clustered in the carboxy-terminal one-third of the mZP3 polypeptide. When all five Ser...
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