Transgenic mice with reduced numbers of functional sperm receptors on their eggs reproduce normally.

doi:10.1091/mbc.6.5.577

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Article

Transgenic mice with reduced numbers of functional sperm receptors on their eggs reproduce normally.

Molecular biology of the cell - 1 May 1995

Liu C, Litscher E S, Wassarman P M

Abstract excerpt

To initiate fertilization in mice, free-swimming sperm bind to mZP3, an approximately 83-kDa glycoprotein present in the ovulated egg zona pellucida (ZP). mZP3 is located periodically along the filaments that constitute the ZP. Sperm recognize and bind to specific oligosaccharides linked to one o...

Topics

Amino Acid Sequence
Animals
Breeding
Egg Proteins
Female
Fertility
Litter Size
Male
Membrane Glycoproteins
Mice
Mice, Transgenic
Molecular Sequence Data
Mosaicism
Mutation
Oocytes
Receptors, Cell Surface
Serine
Sperm-Ovum Interactions

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