Study of the Huntington's disease (HD) gene CAG repeats in schizophrenic patients shows overlap of the normal and HD affected ranges but absence of correlation with schizophrenia.

doi:10.1136/jmg.31.9.690

Article

Study of the Huntington's disease (HD) gene CAG repeats in schizophrenic patients shows overlap of the normal and HD affected ranges but absence of correlation with schizophrenia.

Journal of medical genetics - 1 Sept 1994

Rubinsztein D C, Leggo J, Goodburn S, Crow T J, Lofthouse R, DeLisi L E, Barton D E, Ferguson-Smith M A

Abstract excerpt

The CAG repeats in the Huntington's disease gene were investigated in chromosomes from 71 unrelated schizophrenic persons and 18 patients with schizoaffective disorder in order to determine if any of these patients had abnormal expansions. All of the probands had repeat sizes in the normal range...

Topics

Alleles
Female
Genetic Linkage
Humans
Huntington Disease
Male
Pedigree
Repetitive Sequences, Nucleic Acid
Schizophrenia

Study of the Huntington's disease (HD) gene CAG repeats in schizophrenic patients shows overlap of the normal and HD affected ranges but absence of correlation with schizophrenia.

Abstract excerpt

Topics

Discuss the evidence