Article
Sequence analysis of the CCG polymorphic region adjacent to the CAG triplet repeat of the HD gene in normal and HD chromosomes.
Journal of medical genetics - 1 May 1995
Pêcheux C, Mouret J F, Dürr A, Agid Y, Feingold J, Brice A, Dodé C, Kaplan J C
Abstract excerpt
The CAG expansion responsible for Huntington's disease (HD) is followed by an adjacent polymorphic CCG repeat region which may interfere with a PCR based diagnosis. We have sequenced this region in 52 unrelated HD patients, from both normal and HD chromosomes. Fifty percent of the normal alleles...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Humans
- Huntington Disease
- Linkage Disequilibrium
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Sequence Analysis, DNA