Trinucleotide (CAG) repeat expansion in chromosomes of Spanish patients with Huntington's disease.

doi:10.1007/BF00211028

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Article

Trinucleotide (CAG) repeat expansion in chromosomes of Spanish patients with Huntington's disease.

Human genetics - 1 Nov 1994

Benitez J, Fernandez E, Garcia Ruiz P, Robledo M, Ramos C, Yébenes J

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative and hereditary disease characterized by progressive movement disorders and mental and behavioral abnormalities. The HD gene is an expanding and unstable trinucleotide repeat (CAG repeat sequences). We studied 77 individuals from 38 families with HD...

Topics

Adolescent
Adult
Aged
Alleles
Child
Female
Humans
Huntington Disease
Male
Middle Aged
Repetitive Sequences, Nucleic Acid
Sex Factors
Spain

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