A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

doi:10.1002/j.1460-2075.1994.tb06956.x

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Article

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

The EMBO journal - 15 Dec 1994

Aligue R, Akhavan-Niak H, Russell P

Abstract excerpt

Wee1 protein kinase regulates the length of G2 phase by carrying out the inhibitory tyrosyl phosphorylation of Cdc2-cyclin B kinase. Mutations were isolated that suppressed the G2 cell cycle arrest caused by overproduction of Wee1. One class of swo (suppressor of wee1 overproduction) mutation, ex...

Topics

Amino Acid Sequence
Base Sequence
Cell Cycle
Cell Cycle Proteins
Enzyme Stability
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Lethal
HSP90 Heat-Shock Proteins
Hot Temperature
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Protein-Tyrosine Kinases

Schizosaccharomyces

Schizosaccharomyces pombe Proteins

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 7813446
DOI: 10.1002/j.1460-2075.1994.tb06956.x
PMCID: PMC395589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7813446-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.PMID 7813446Read ↗

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Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.Semantic proximity Read ↗

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Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization.Semantic proximity Read ↗

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