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Article

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

The EMBO journal - 15 Dec 1994

Aligue R, Akhavan-Niak H, Russell P

Abstract excerpt

Wee1 protein kinase regulates the length of G2 phase by carrying out the inhibitory tyrosyl phosphorylation of Cdc2-cyclin B kinase. Mutations were isolated that suppressed the G2 cell cycle arrest caused by overproduction of Wee1. One class of swo (suppressor of wee1 overproduction) mutation, exemplified by swo1-26, also caused a temperature sensitive lethal phenotype in a wee1+ background. The swo1+ gene...

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Identifiers

PMID: 7813446
DOI: 10.1002/j.1460-2075.1994.tb06956.x
PMCID: PMC395589

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