Article
Stimulation of genetic instability and associated large genomic rearrangements in Streptomyces ambofaciens by three fluoroquinolones.
Antimicrobial agents and chemotherapy - 1 Sept 1994
Volff J N, Vandewiele D, Decaris B
Abstract excerpt
In Streptomyces ambofaciens NSA2002, pigmented wild-type colonies spontaneously give rise to pigment-negative (Pig-) mutants at a frequency of about 0.5%. This genetic instability is related to large deletions which can be associated with amplifications of DNA sequences. The influence of three fl...
Topics
- Anti-Infective Agents
- Ciprofloxacin
- DNA, Bacterial
- Enoxacin
- Gene Amplification
- Gene Deletion
- Gene Rearrangement
- Genome, Bacterial
- Humans
- Models, Biological
- Mutation
- Norfloxacin
- Pigmentation
- Stimulation, Chemical
- Streptomyces