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Article

Stimulation of genetic instability and associated large genomic rearrangements in Streptomyces ambofaciens by three fluoroquinolones.

Antimicrobial agents and chemotherapy - 1 Sept 1994

Volff J N, Vandewiele D, Decaris B

Abstract excerpt

In Streptomyces ambofaciens NSA2002, pigmented wild-type colonies spontaneously give rise to pigment-negative (Pig-) mutants at a frequency of about 0.5%. This genetic instability is related to large deletions which can be associated with amplifications of DNA sequences. The influence of three fluoroquinolones (ciprofloxacin, enoxacin, and norfloxacin) on this property was investigated. At a survival rate higher...

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Source

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Identifiers

PMID: 7811007
DOI: 10.1128/AAC.38.9.1984
PMCID: PMC284672

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Source receipt: pubmed, retrieved 7 Sept 2026.

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