Stimulation of genetic instability in Streptomyces ambofaciens ATCC 23877 by antibiotics that interact with DNA gyrase.

doi:10.1099/00221287-139-11-2551

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Article

Stimulation of genetic instability in Streptomyces ambofaciens ATCC 23877 by antibiotics that interact with DNA gyrase.

Journal of general microbiology - 1 Nov 1993

Volff J N, Vandewiele D, Simonet J M, Decaris B

Abstract excerpt

In wild-type Streptomyces ambofaciens ATCC 23877, pigment-defective (Pig-) mutants arise at a frequency of about 0.5%; this genetic instability is related to genomic rearrangements such as deletions and/or amplifications of DNA sequences. On media containing oxolinic acid and novobiocin, which in...

Topics

Anti-Bacterial Agents
DNA Topoisomerases, Type II
DNA, Bacterial
Mutation
Phenotype
SOS Response, Genetics
Streptomyces

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