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Article

Stimulation of genetic instability in Streptomyces ambofaciens ATCC 23877 by antibiotics that interact with DNA gyrase.

Journal of general microbiology - 1 Nov 1993

Volff J N, Vandewiele D, Simonet J M, Decaris B

Abstract excerpt

In wild-type Streptomyces ambofaciens ATCC 23877, pigment-defective (Pig-) mutants arise at a frequency of about 0.5%; this genetic instability is related to genomic rearrangements such as deletions and/or amplifications of DNA sequences. On media containing oxolinic acid and novobiocin, which interact with the A and B subunits of DNA gyrase, respectively, the frequency of variants increased dramatically. The...

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PMID: 8277240
DOI: 10.1099/00221287-139-11-2551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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