Intrinsic or acquired drug resistance and metastasis: are they linked phenotypes?

doi:10.1002/jcb.240560108

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Article

Intrinsic or acquired drug resistance and metastasis: are they linked phenotypes?

Journal of cellular biochemistry - 1 Sept 1994

Kerbel R S, Kobayashi H, Graham C H

Abstract excerpt

Evidence is reviewed which suggests a linkage may exist between certain forms of de novo or acquired drug resistance and metastasis. This includes the finding that expression of certain dominantly acting mutant oncogenes or tumor suppressor genes, i.e., genes which normally act to "drive" tumor p...

Topics

Animals
Cell Line
Drug Resistance
Genes, Tumor Suppressor
Humans
Mutation
Neoplasm Metastasis
Oncogenes
Phenotype
Proto-Oncogenes
Tumor Cells, Cultured

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