Article
Selective transmission of variant genomes from mother to infant in neonatal fulminant hepatitis B.
Hepatology (Baltimore, Md.) - 1 Jan 1995
von Weizsäcker F, Pult I, Geiss K, Wirth S, Blum H E
Abstract excerpt
Hepatitis B virus (HBV) nucleotide sequences isolated from mother/child pairs were analyzed in three cases of neonatal fulminant hepatitis B (FHB). Heterogeneous HBV sequences consistent with both adw2 and ayw subtype were found in all three mothers. In one case, in which the child survived, both subtypes were transmitted. By contrast, only the ayw subtype was present in the two other children with a fatal course...
Topics
- Adult
- Base Sequence
- Female
- Genetic Variation
- Genome, Viral
- Hepatitis B
- Hepatitis B Core Antigens
- Humans
- Infant, Newborn
- Maternal-Fetal Exchange
- Molecular Probes