Article
[Selective transmission of hepatitis B virus variant with S gene mutation between HBV-carrier mothers and their infants].
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA - 1 Sept 2002
Zhang Jin, Wang Zhan-hui, Hou Jin-lin, Yang Hong, Cheng Ai-lin, Li Xiu-hui
Abstract excerpt
OBJECTIVE: To investigate the role of hepatitis B virus (HBV) DNA levels in HBV-carrier mother and selective transmission of HBV variant with S gene mutation to infant in the failure of neonatal HBV immunization. METHODS: Serum HBV DNA level was determined by Roche LightCycler quantities in 95 HBsAg-positive pregnant women and later in their newborns. Hepatitis B virus S gene sequences isolated from mother/child...
Topics
- Adult
- Carrier State
- DNA, Viral
- Female
- Genetic Variation
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B Vaccines
- Hepatitis B virus
- Humans
- Infant, Newborn
- Infectious Disease Transmission, Vertical
- Mutation
- Pregnancy