An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees.

doi:10.1111/j.1469-1809.1994.tb00731.x

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Article

An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees.

Annals of human genetics - 1 Oct 1994

Lin S, Thompson E, Wijsman E

Abstract excerpt

Exact probability and likelihood computation on complex pedigrees is often infeasible, since exact methods are too computationally intensive even with today's computing technology. A statistical tool, Markov chain Monte Carlo (MCMC), is increasingly being explored as a technique for estimating pr...

Topics

Algorithms
Genotype
Humans
Markov Chains
Models, Genetic
Monte Carlo Method
Pedigree

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