Article
An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees.
Annals of human genetics - 1 Oct 1994
Lin S, Thompson E, Wijsman E
Abstract excerpt
Exact probability and likelihood computation on complex pedigrees is often infeasible, since exact methods are too computationally intensive even with today's computing technology. A statistical tool, Markov chain Monte Carlo (MCMC), is increasingly being explored as a technique for estimating probabilities of genotypic configurations on pedigrees conditional on phenotypic data. However, this conditional...
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