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Article

Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.

Diabetes - 1 Jun 1995

Byrne M M, Sturis J, Fajans S S, Ortiz F J, Stoltz A, Stoffel M, Smith M J, Bell G I, Halter J B, Polonsky K S

Abstract excerpt

This study was undertaken to test the hypothesis that the diabetes susceptibility gene on chromosome 20q12 responsible for maturity-onset diabetes of the young (MODY) in a large kindred, the RW family, results in characteristic alterations in the dose-response relationships between plasma glucose concentration and insulin secretion rate (ISR) that differentiate this form of MODY from MODY in subjects with...

Topics

Adult
Blood Glucose
Chromosomes, Human, Pair 20
Diabetes Mellitus, Type 2
Dose-Response Relationship, Drug
Family
Female
Genes
Glucose
Humans
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin Secretion

Male

Mutation

Source

Identifiers

PMID: 7789636
DOI: 10.2337/diab.44.6.699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789636-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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