Article
Mitochondrial mutations and human disease.
Environmental and molecular mutagenesis - 1 Jan 1995
Grossman L I
Abstract excerpt
The mitochondrial genome is essential for producing ATP (adenosine 5'-triphosphate) via oxidative phosphorylation. The gradual decline of mitochondrial function with age has long been postulated as a factor in aging. More recently, a variety of diseases have been related to molecular defects in human mitochondrial DNA. In both the cases of aging and disease, symptoms were generally neuromuscular, reflecting the...
Topics
- Aging
- Animals
- Base Sequence
- DNA, Mitochondrial
- Environmental Pollutants
- Genetic Diseases, Inborn
- Humans
- Molecular Sequence Data
- Mutagens
- Mutation