Article
Microsatellite D21S210 (GT-12) allele frequencies in sporadic Alzheimer's disease.
Acta neurologica Scandinavica - 1 Feb 1995
Lannfelt L, Lilius L, Viitanen M, Houlden H, Rossor M, Hardy J, Winblad B, Basun H
Abstract excerpt
Four disease-causing mutations have so far been described in the amyloid precursor protein gene on chromosome 21 in familial early-onset Alzheimer's disease. Linkage analysis with a fourteen-allele microsatellite at D21S210 named GT-12 has proven useful in the elucidation of amyloid precursor pro...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Chromosomes, Human, Pair 21
- DNA, Satellite
- Female
- Gene Frequency
- Humans
- Male
- Middle Aged
- Models, Genetic
- Polymerase Chain Reaction
- Reference Values
- Sweden
- United Kingdom