Article
New frontiers in Alzheimer's disease genetics.
Neuron - 25 Oct 2001
Tanzi R E, Bertram L
Abstract excerpt
Alzheimer's disease (AD) is a genetically complex disorder that accounts for the majority of dementia in the elderly population. Over 100 rare, highly penetrant mutations have been described in three genes (APP, PSEN1, PSEN2) for early-onset familial AD. In the more common late-onset form, a polymorphism in the apolipoprotein E gene has been associated with increased susceptibility. However, recent studies...
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