Article
Effects of transforming growth factor beta 1 on the adenylyl cyclase-cAMP pathway in prostate cancer.
Growth factors (Chur, Switzerland) - 1 Jan 1994
Steiner M S, Wand G S, Barrack E R
Abstract excerpt
We reported previously that MATLyLu rat prostate cancer cells engineered to overproduce transforming growth factor beta 1 (TGF beta 1) produce larger, more metastatic tumors in vivo. We recognized that this ability of TGF beta 1 to act as a positive modulator of prostate tumor behavior might be due to effects of TGF beta 1 on the host and/or on the tumor cells. In this study we demonstrated that the cells...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Adenylyl Cyclases
- Animals
- Cell Division
- Cell Line
- Colforsin
- Cyclic AMP
- GTP-Binding Proteins
- Guanosine 5'-O-(3-Thiotriphosphate)
- Kinetics
- Male