Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The loss of TGF-beta signaling promotes prostate cancer metastasis.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Tu William H, Thomas Tania Z, Masumori Naoya, Bhowmick Neil A, Gorska Agnieszka E, Shyr Yu, Kasper Susan, Case Tom, Roberts Richard L, Shappell Scott B, Moses Harold L, Matusik Robert J

Abstract excerpt

In breast and colon cancers, transforming growth factor (TGF)-beta signaling initially has an antineoplastic effect, inhibiting tumor growth, but eventually exerts a proneoplastic effect, increasing motility and cancer spread. In prostate cancer, studies using human samples have correlated the loss of the TGF-beta type II receptor (T beta R II) with higher tumor grade. To determine the effect of an inhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to In Situ Hybridization
Share to Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Prostate

Share to Prostatic Neoplasms

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Transforming Growth Factor beta

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 12869309
DOI: 10.1016/S1476-5586(03)80058-1
PMCID: PMC1502411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The loss of TGF-beta signaling promotes prostate cancer metastasis.PMID 12869309Read ↗

Modeling prostate cancer in mice: limitations and opportunities.Semantic proximity Read ↗

TGFβ signaling limits lineage plasticity in prostate cancer.Semantic proximity Read ↗

Survey of genetically engineered mouse models for prostate cancer: Analyzing the molecular basis of prostate cancer development, progression, and metastasisSemantic proximity Read ↗

Prostate cancer in a transgenic mouse.Semantic proximity Read ↗

TGFBR3 loss and consequences in prostate cancerSemantic proximity Read ↗

The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to BoneSemantic proximity Read ↗

A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer.Semantic proximity Read ↗

Models of metastatic prostate cancer: a transgenic perspectiveSemantic proximity Read ↗

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.Semantic proximity Read ↗

Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?Semantic proximity Read ↗

Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancerSemantic proximity Read ↗

Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.