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Article

Clonal diversity in the expression and stability of the metastatic capability of Leishmania guyanensis in the golden hamster.

The Journal of parasitology - 1 Aug 2000

Martínez J E, Valderrama L, Gama V, Leiby D A, Saravia N G

Abstract excerpt

Metastatic disease is a major concern of dermal leishmaniasis caused by Leishmania of the Viannia subgenus. The golden hamster provides an experimental model of systemic dissemination and cutaneous metastasis of Leishmania Viannia. We have exploited this model to examine the expression of parasite virulence in cloned populations derived from a strain of L. guyanensis previously shown to be highly metastatic in...

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PMID: 10958458
DOI: 10.1645/0022-3395(2000)086[0792:CDITEA]2.0.CO;2

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