Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells.

doi:10.1007/BF00295501

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Article

Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells.

Current microbiology - 1 May 1995

Chittum H S, Champney W S

Abstract excerpt

Erythromycin and other macrolide antibiotics have been examined for their effects on ribosome assembly in growing Escherichia coli cells. Formation of the 50S ribosomal subunit was specifically inhibited by erythromycin and azithromycin. Other related compounds tested, including oleandomycin, cla...

Topics

Anti-Bacterial Agents
Azithromycin
Drug Resistance, Microbial
Erythromycin
Escherichia coli
Escherichia coli Proteins
Mutation
Peptide Chain Elongation, Translational
Protein Biosynthesis
RNA-Binding Proteins
Ribosomal Proteins
Ribosomes
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 7766155
DOI: 10.1007/BF00295501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7766155-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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