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Article

An n-allele model for progressive amplification in the FMR1 locus.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995

Morris A, Morton N E, Collins A, Macpherson J, Nelson D, Sherman S

Abstract excerpt

An n-allele model is developed for the FMR1 locus, which causes the fragile X syndrome, where n is the number of triplet repeats in the first exon. Frequencies in the general population and in index families are used to generate an n to n + delta transition matrix that predicts specific risks in satisfactory agreement with observation. However, until sequencing distinguishes between stable and unstable alleles...

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Identifiers

PMID: 7761409
DOI: 10.1073/pnas.92.11.4833
PMCID: PMC41801

Genes

FMR1

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An n-allele model for progressive amplification in the FMR1 locus.PMID 7761409Read ↗

Population genetics of the fragile-X syndrome: multiallelic model for the FMR1 locus.Semantic proximity Read ↗

Expansion to full mutation of a FMR1 intermediate allele over two generations.Semantic proximity Read ↗

Population genetics of fragile X: a multiple allele model with variable risk of CGG repeat expansion.Semantic proximity Read ↗

Screening and instability of FMR1 alleles in a prospective sample of 24,449 mother-newborn pairs from the general population.Semantic proximity Read ↗

Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1.Semantic proximity Read ↗

Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox.Semantic proximity Read ↗

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.Semantic proximity Read ↗

Hierarchical Bayes model for random haplotype and family effects in the transmission of fragile-X.Semantic proximity Read ↗

Genetic variation and intergenerational FMR1 CGG-repeat stability in 100 unrelated three-generation families from the normal population.Semantic proximity Read ↗

Haplotype study of intermediate-length alleles at the fragile X (FMR1) gene: ATL1, FMRb, and microsatellite haplotypes differ from those found in common-size FMR1 alleles.Semantic proximity Read ↗

Comment: How many are too many when discussing triplet repeats in the FMR1 gene and the Fragile X syndrome?Semantic proximity Read ↗

Sequence analysis of the fragile X trinucleotide repeat: implications for the origin of the fragile X mutation.Semantic proximity Read ↗

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