Article
Haplotype study of intermediate-length alleles at the fragile X (FMR1) gene: ATL1, FMRb, and microsatellite haplotypes differ from those found in common-size FMR1 alleles.
Human biology - 1 Feb 2005
Curlis Yvette, Zhang Cuiling, Holden Jeanette J A, Loesch P Ken Kirkby Danuta, Mitchell R John
Abstract excerpt
The CGG repeat within the X-chromosome-linked FMR1 gene, which in hyperexpansion (> 200 copies) results in fragile X syndrome, is highly polymorphic. The mechanism of expansion is not well understood, but CGG repeats called intermediate-length or gray zone alleles (approximately equal 35-60 repeats) are thought to make up the FMR1 alleles showing initial steps in this expansion process. It has been hypothesized...
Topics
- Adolescent
- Alleles
- Child
- Child, Preschool
- DNA Primers
- Female
- Fragile X Mental Retardation Protein
- Fragile X Syndrome
- Gene Frequency
- Genetic Markers
- Haplotypes
- Humans
- Male
- Mutation