Article
Differential sodium regulation between salt-sensitive and salt-resistant Sabra rats is not due to any mutation in the renal alpha 2B-adrenoceptor gene.
American journal of hypertension - 1 Feb 1995
Le Jossec M, Cloix J F, Pecquery R, Giudicelli Y, Dausse J P
Abstract excerpt
A defect in sodium modulation of density and agonist affinity of renal alpha 2-adrenoceptor exists in normotensive salt-resistant Sabra (SBN) rats when compared to hypertensive salt-sensitive (SBH). A highly conserved aspartic acid residue in the second helix has been implicated in sodium regulat...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA
- Electrophoresis
- Gene Amplification
- Genome
- Hypertension
- Male
- Molecular Sequence Data
- Mutation
- Rats
- Receptors, Adrenergic, alpha-2
- Sodium