Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a beta-subunit variant.

doi:10.1073/pnas.92.10.4309

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Article

Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a beta-subunit variant.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 1995

Quiroga S, Garofalo R S, Pfenninger K H

Abstract excerpt

Nerve growth cones isolated from fetal rat brain are highly enriched in a 97-kDa glycoprotein, termed beta gc, that comigrates with the beta subunit of the IGF-I receptor upon two-dimensional PAGE and is disulfide-linked to this receptor's alpha subunit. Antibodies prepared to a conserved domain...

Topics

Animals
Blotting, Western
Brain
Cell Fractionation
Cell Membrane
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Fetus
Genetic Variation
Macromolecular Substances
Molecular Weight
Neurons
Phosphorylation
Rats
Rats, Sprague-Dawley
Receptor, IGF Type 1
Receptor, Insulin

Source

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Identifiers

PMID: 7753803
DOI: 10.1073/pnas.92.10.4309
PMCID: PMC41933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7753803-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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