Article
Central nervous system-specific glycosylation of the type A natriuretic peptide receptor.
Endocrinology - 1 Jan 2002
Müller Dieter, Middendorff Ralf, Olcese James, Mukhopadhyay Amal K
Abstract excerpt
Physiological effects of atrial natriuretic peptide (ANP) are thought to be mediated by binding to and activation of a widely expressed membrane receptor, termed guanylyl cyclase (GC)-A. During comparative analyses of ANP receptor expression in various rat and bovine tissues, by UV light-induced affinity cross-linking to (125)I-ANP, we uncovered a size heterogeneity of GC-A, detectable as a 130-kDa protein in...
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